Here are the data for two pain relieving drugs used to manage severe postoperative pain.

Consider the following:

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Here are the data for two pain relieving drugs used to manage severe postoperative pain. Both are able to relieve pain completely, provided the proper dose is given.

o Drug A: ED50 = 10 mg // LD50 = 500mg

o Drug B : ED50 = 1 mg // LD50 = 20mg

§ Which drug is most efficacious?

§ Which drug is the most potent?

§ Which has the greatest therapeutic index?

§ Which is safer to administer?

§ Which causes the fewest side effects?

Expert Answer

ED 50 means effective dose for 50%of the population.. LD 50 means median lethal dose level 50%.. Oral LD 50 of drug is 229.2mg/kg and ED50 is 0.0125_1mg/kg.. Which drug is most efficacious? Drug B:ED 50=1mg//LD50=20mg doses are effecti…

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