Pyruvate is a branch point in metabolism. Construct a diagram to illustrate that pyruvate is at a metabolic branch point, making use of all the metabolic reactions that pyruvate can be involved in. Include in your diagram the reactions involved in NAD+ regeneration under anaerobic conditions in mammals, the first reaction of gluconeogenesis to synthesize glucose from pyruvate, the last reaction of glycolysis to form pyruvate and the use of pyruvate in an aminotransferase reaction. Make sure to include the names and structures of the compounds. Include all enzyme names and any cofactor requirements. Also indicate the compartment within the cell where these reactions take place.
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